The complex relationship between metabolic syndrome and sweeteners

Metabolic syndrome is a multifactorial disorder originating from central obesity through high caloric intake and sedentary lifestyle. increases the risk of type 2 diabetes (T2D) disease, converting it to one costliest chronic diseases, which reduces life quality. A strategy proposed by food industry reduce this problem generation low-caloric products using sweeteners, are compounds that can substitute sucrose, given their sweet taste. For many years, was assumed sweeteners did not have relevant interaction in metabolism. However, recent studies demonstrated interact either with metabolism or gut microbiota, sweet-taste receptors play an essential role. This review presents overview industrial application most commonly consumed sweeteners. In addition, within body, including absorption, distribution, metabolism, microbiota excretion also reviewed. Furthermore, complex relationship between metabolic discussed, presenting results vivo clinical trials. Findings indicate that, order formulate sugar-free noncaloric for market, several factors need be considered, dose, proportions, human receptors. More studies, syndrome, needed better understand as well possible effect on dysbiosis.